Space Chimps follows the tale of Ham, a mischievous circus chimpanzee who just so happens to be the grandson of the first chimp ever to go into outer space. Ham agrees to take part in a publicity stunt which involves him being launched into orbit in order to investigate a distant new planet. Needless to say, the spaceship crash-lands, he finds his friends' lives have been put in peril at the hands of evil tyrannical overlord King Zartog, and only Ham can save the day.